ABSTRACT
Biochemical Changes in serum of male albino rats treated with aqueous leaf extract of Phyllanthus amarus were examined. 50mg/kg and 100mg/kg of the extracts were administered orally and once daily to group I and group II of test animals respectively for 28 days. The third group which served as control received distilled water only. On the 29th day, the rats which had been fasted overnight were dissected under chloroform anaesthesia and their blood collected directly by cardiac puncture. The blood was allowed to clot and centrifuged to obtain serum which was kept in a refrigerator at - 200C until its usage for the analysis of the following parameters; alanine and aspartate transaminases, alkaline and acid phosphatases, haemoglobin concentration, high and low density lipoproteins. The result indicates significant (P<0.05) increases in AST, ALT and ACP levels in tests groups compared to the control animals. There were non-significant elevation in the concentration of ALP, HDL, LDL and haemoglobin. These results suggest that P. amarus may be toxic if abused but when properly administered can be of use for its medicinal values.